Experiments have shown that USAG-1 deficiency causes overgrowth of teeth in animal models. Researchers from Kyoto University in Japan have suggested that an antibody against USAG-1 may stimulate the growth of dormant teeth in people suffering from dental agenesis. Although humans were thought to have only two sets of teeth (deciduous and permanent), “dormant germs” of a third set have recently been discovered. “We want to do something to help those who suffer from the loss or absence of teeth. Although there is currently no treatment that would allow a permanent cure, we believe that people have high hopes for teeth growth,” Katsu told The Mainichi Takahashi, co-author of the study and director of the Department of Oral and Maxillofacial Surgery at Kitano Hospital (Osaka). Will it be available on the market by 2030? To confirm their hypothesis, the Japanese researchers conducted several in vivo tests on mice and ferrets, the most recent of which dates back to last year. The trials assessed the effectiveness and safety of a series of anti-UCAG-1 antibodies in causing excess tooth growth. More specifically, the antibodies blocked the interaction of USAG-1 with BMP and Wnt. As a result, animals exhibited reduced fertility and survival rates using the Wnt pathway, given its involvement in skeletal development from the embryonic stage. In contrast, for the BMP pathway, a single drug administration was sufficient to form a third-generation supernumerary tooth.
Sharlene May
Excitation of thorium-229 brings closer the creation of working nuclear clocks
Now let’s take a laser – a concentrated beam of light. If we tune the frequency of this laser to exactly match the energy required to cause this energy jump in a given electron, something very special will happen. The electron absorbs the laser energy and moves to a higher energy level. But this state is unstable, so the electron quickly returns to its original state, emitting a photon, or a small packet of light. It is this phenomenon that is particularly interesting for clocks: the frequency at which photons are emitted is extremely precise and constant. It directly depends on the energy difference between the electronic levels of the atom. By measuring this frequency we can obtain a very precise measurement of time. To put it simply, it is as if each tick of a clock was the result of an electron making a small energy jump in the atom.
NASA plans to create a levitating robotic train to transport cargo on the Moon
Another example is BioSentinel. This project is exploring the possibility of sending an interplanetary mission aboard a small satellite to study the effects of cosmic radiation on living organisms. As part of this program, NASA recently greenlit a promising and ambitious new project called Flexible Levitation on a Track (FLOAT). FLOAT envisions the creation of a lunar rail transport system that could revolutionize our understanding of transportation on the Moon. Levitating cars The FLOAT project is based on the use of levitating magnetic robots that move along a three-layer film track. This innovative design will reduce abrasive wear caused by lunar dust and provide an efficient means of transporting payloads across the lunar surface. The technology also minimizes risk to astronauts by reducing the need for human movement on the lunar surface. These robots will carry carts traveling at about 1.60 km/h, capable of transporting up to 100 tons of materials per day to and from NASA’s future lunar base. FLOAT’s main goal will be to create a reliable, autonomous and efficient transport system for moving materials on the Moon, with daily operations planned to begin as early as the 2030s.
SpaceX prepares for next Starship flights, but pushes fourth launch to June
It all started on May 8th with a static fire test of Ship 30, which successfully launched all six of its Raptors. This ship will fly after Ship 29 and will be paired with Booster 12, which already underwent tank leak testing in January. On May 10, Ship 30 returned to the construction site, clearing the suborbital pad, which workers immediately began dismantling. Starship engine launch tests will no longer be carried out near the launch pad, but at the site in Massey. Ship 26, a prototype without wings and a heat shield, which will be used for the first time on the new static fire test stand, was also transported here on May 8. This stand is very different from those used so far for Starship, since for the first time a “trench” was dug for it to better control the exhaust gases. Ship 26 will be the first to test all engine testing equipment. Ship 31 also arrived at Massey on May 11 to test its tanks with liquid nitrogen, which will be used for Starship’s sixth flight. Also on May 11, SpaceX installed RN-11 on the launch pad for the second time. She had been on site since April 8, after all 33 Raptor engines were fired three days earlier.
Google and Harvard researchers present the most detailed map of the human brain to date
On the other hand, today pathologies can be reproduced in cell cultures or organoids. However, there are very few models that reliably reflect diseases affecting the brain. Moreover, although animals are fairly good models for studying some diseases, their brains—and even the brains of other primates—are radically different from our own. To fill the gaps, many atlases have been created to map the connections between neurons in the human brain, but most of them have only limited resolution. This type of atlas, called a “connect,” allows us to trace the complexity of connections at the level of an individual neuron. According to the Harvard and Google team, nanoscale mapping is necessary to expand our understanding of how the brain works and the mechanisms of the diseases that affect it.
China is considering a complete ban on diesel and gasoline cars
According to the World Association of Automobile Manufacturers, 28 million cars were produced in China last year, including 500,000 electric vehicles.
The publication notes that China follows France and the UK, which also intend to ban the production of gasoline and diesel cars from 2040.
In July 2017, it was reported that Volvo plans to stop producing cars equipped only with an internal combustion engine. Starting from 2019, all the company’s passenger cars will be equipped with electric power plants as the main engine or in combination with a gasoline engine (hybrid).
In turn, the American manufacturer Ford expects that by 2025, up to 70 percent of cars sold in China will be equipped with electric motors.
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Apple and Google retain their leadership among the world’s most valuable brands
Coca-Cola lost five percent of its brand value over the year (estimated at $69.3 billion) and dropped one place in the ranking, taking fourth place. It is followed by Amazon ($64.8 billion), Samsung ($56.2 billion), Toyota ($50.3 billion). For the first time, the social network Facebook (48.2 billion) entered the top ten of the Interbrand rating, the brand value of which increased by 48 percent over the year, in ninth and tenth place are Mercedes-Benz ($47.8 billion) and IBM ($46.8 billion), respectively. .
Google, Apple, Microsoft, Amazon and Facebook also feature in the top 10 of another global brand value ranking compiled by Britain’s Kantar Millward Brown.
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The European Commission has decided to recover hundreds of millions of euros from American corporations
At stake are billions of euros in fiscal fees that companies have not paid by taking refuge in convenient jurisdictions. The source said that similar decisions could soon be made regarding McDonald’s Corporation, which will have to pay an additional $500 million in taxes.
According to EC documents, since 2009, the European branch of the McDonald’s chain has paid 1.49 percent of taxes on $1.8 billion in profits to the EU budget. At the same time, the amount of taxes in Luxembourg, where the company’s headquarters is located, was supposed to be 29.2 percent of profits.
Expanded Panama Canal increases congestion at US East Coast ports
At the beginning of October, the 2,000th New Panamax class container ship passed through the Panama Canal. The total tonnage of ships passing through the canal since the beginning of 2017 has increased by almost a quarter compared to the same period in 2016.
They note that delivering cargo from Asia by sea to US East Coast ports, including New York, is now cheaper and faster. Previously, transport routes were built through West Coast ports, and from there containers and other cargo, including energy, were sent to the eastern United States by rail or road transport across the entire continent.
The Panama Canal, opened in 1920, connects the Pacific Ocean with the Caribbean Sea and the Atlantic Ocean. In September 2007, it was decided to build a new sluice gate. The reconstruction ended on June 26, 2016.
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HADI cycles are part of the Agile methodology. The essence of the HADI cycle method consists of four main stages:
The HADI cycle includes:
Choosing a hypothesis (Hypothesis). Search for a specific business idea to be tested. For example, if you cover delivery vehicles with store advertising, sales will increase by at least 5%.
Actions, hypothesis testing (Actions). Hypothesis testing phase for a limited time. The duration of hypothesis testing does not exceed two weeks. It is recommended to test mailings not by time, but by the number of letters sent: about 200-300 pieces.
Analysis of the obtained result (Data). Data collection stage. In the example of the advertising campaign for a store on cars, it turned out to be successful: the idea can be scaled. The data can be any metrics: number of sales, conversion, and others.
Conclusions. The final stage, when the hypothesis is confirmed or refuted depending on the result obtained. If the hypothesis is successful, the idea can be scaled up. If the hypothesis is not confirmed, look for other solutions.
After completing one HADI cycle, the next hypothesis can be tested. The HADI cycle allows you to save money by testing a business idea for a small amount of time or in a small area.